Research
Boost Immune System
Well-Nourished Women Maintain Ability To Ward Off Disease
In Old Age
1-26-2000
University Park, Pa. --- Contrary to previous reports, healthy,
well-nourished older women, 60 to 80 years of age, have
immune systems that function at levels similar to young
women, 20 to 40 years old, a Penn State study has shown.
Dr.
Namanjeet Ahluwalia, assistant professor of nutrition and
leader of the study, says, "Although previous studies
had, for the most part, indicated a general age-related
decline in immune function, our study suggests that, when
nutritional and health status are maintained, the body's
ability to defend itself against viruses, bacteria, or tumor
cells may not necessarily be affected with aging per se."
The
results suggest that healthy eating habits may offer a natural
means to maintain the ability to fight off germs and reduce
illness in old age, she adds.
The
results of the study are detailed in the current issue of
the journal Mechanisms for Aging and Development. The authors
are Deanna Krause, Dr. Ahluwalia's former master's degree
student; Dr. Andrea Mastro, professor of microbiology and
cell biology; Dr. Gordon Handte, medical director of the
clinical laboratory at Penn State's University Health Services;
Dr. Helen Smicklas-Wright, professor of nutrition; Dr. Mary
P. Miles, Penn State postdoctoral researcher; and Dr. Ahluwalia.
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The authors note in their paper, "The lack of
age-associated changes in immune response in the current study is
in contrast to most of the previous literature on aging and immune
function where overall adequacy of nutritional status and/or health
status were not simultaneously considered in the study design."
In the Penn State study, 75 women between the ages
of 60 and 80 were recruited to participate with the assistance of
local Agencies on Aging. Thirty-five younger women, ages 20 to 40
were also recruited for comparison. Women between 41 and 59 were not
included due to the confounding effects of hormonal changes on immune
function associated with menopause.
All of the study participants were screened to exclude
individuals with acute or chronic inflammation and other medical conditions.
They were also screened for undernutrition, and protein, iron, vitamin
B12 and folate status. Analysis and comparison of blood samples from
the generally healthy and well-nourished older and young participants
showed "most immune parameters were not compromised with aging."
"These findings highlight the importance of simultaneous
examination of health and nutritional status in studies of immune
function with aging," the researchers write.
In conclusion, the authors add that nutritional status
should also be evaluated in conjunction with defining a person's health
status and that future studies are needed to examine the interaction
of specific nutrients with aging and immune response.
The study was supported by grants from the U.S. Department
of Agriculture and the National Cattlemen's Beef Association.
This
story has been adapted from a news release issued by Penn State, www.psu.edu.
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